The Clinical AI Value Alignment lab studies artificial intelligence (AI) used in healthcare settings. We focus on algorithmic notions of interpretability, fairness, accuracy, and robustness in medical applications of AI.

The lab is part of the Computational Health Informatics Program at Boston Children’s Hospital, affiliated with Harvard Medical School.

Recent Papers

A pre-train and fine-tune framework for adaptive boosting of pre-trained polygenic risk scores
Jie Hu, Raelynn Chen, Maxwell Salvatore, Olivia Wu, Okan Bilge Ozdemir, Yiwen Lu, Shawn N. Murphy, Elizabeth W. Karlson, Atlas Khan, Krzysztof Kiryluk, Iftikhar J. Kullo, Johanna L. Smith, Eimear E. Kenny, Yuan Luo, Zaldy S. Tan, William G. La Cava, Marylyn D. Ritchie, Yong Chen, Ruowang Li (2026)
Nature Communications
A foundation-model approach to pediatric headache classification from rs-fMRI
Guilherme S. Imai Aldeia, Clara Moon, Julie Shulman, Navil Sethna, Allison Smith, Alyssa Lebel, William G. La Cava, Scott Holmes (2026)
Machine Learning for Healthcare Conference
Single lead electrocardiographic detection of left ventricular systolic dysfunction in pediatric and congenital heart disease
Joshua Mayourian, Ivor B. Asztalos, William La Cava, Ryan L. Kobayashi, Sunil J. Ghelani, Victoria L. Vetter, Rachel M. Wald, Anne Marie Valente, Tal Geva, John K. Triedman (2026)
npj Digital Medicine

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